Hematopathologic Phenotypes Made Mockingly Simple

A remedy for CDphobia

Margaret Uthman, MD

University of Texas Houston School of Medicine
Department of Pathology and Laboratory Medicine

Artwork and layout by Ed Uthman, MD

Last updated 17 Jun 2000

These two charts represent attempts at simplification of the antigen profiles used in the diagnostic workup of lymphomas and leukemias. It is important to note that many cases of each of these diagnostic entities do not perfectly fit the profiles as indictated in the following charts.

Lymphoid proliferations

[Lymphocytosis flow chart,
greyscale GIF, 33K]

A larger version (39K) of this chart is also available.

Blast proliferations

A larger version (33K) of this chart is also available.

Here are a few other useful Web sites related to this topic:

REAL lymphoma classification (University of Washington)
WHO Classification of Neoplastic Diseases of the Hematopoietic and Lymphoid Tissues (Society for Hematopathology)
Flow cytometry links from the Salk Institute
List of CD antigens, from NIH.
CancerNet PDQ Treatment Statements for Physicians is a product of the National Cancer Institute, but this Web implementation from the University of Bonn is much better than the actual NCI site. Links to relevant diseases are as follows:
Consensus Document on Leukemia Immunophenotyping from the European Working Group on Clinical Cell Analysis. This has lots of technical information.

Much thanks to Jeffrey Winters, MD, and his colleagues at the University of Kentucky, and to Richard Miller, MD, for their invaluable comments and suggestions.